On the 12th February 1698, James was served heir to his father Thomas Lidderdale of Sanct Mary Isle. He married Margaret, youngest daughter of Andrew Heron of Kirouchtrie, and widow (without issue) of John M'Kie of Larg, parish of Minnigaff. By her he had issue:
- -, daughter, who married John Douglas, surgeon.
Source: P.H. McKerlie, History of the Lands and Their Owners in Galloway, 1878.